Welcome to the United Kingdom Environmental Mutagenesis Society Conference 2016 website, the home of information for the 39th annual meeting. The conference will run from Sunday 26th June to Wednesday 29th June 2016 at King’s College, London.

All details about the conference including ‘Registration’ and ‘Abstract Submission’ tabs can be found by clicking on the links in the top menu.

For further details about the conference please contact ukems@affinityevents.co.uk

Invitation and WelcomeKCL_logo_redVolker_1

It is a great pleasure to cordially invite you to join us Sunday 26th June to Wednesday 29th June 2016 in London for the 39th Annual Meeting of the United Kingdom Environmental Mutagen Society (UKEMS). The conference will be held at King’s College London.

The UKEMS meeting will covers all
aspects in relation to DNA damage and mutations caused by environmental agents. The organisers thank the Industrial Genotoxicology Group (IGG), the Molecular Epidemiology Group (MEG) and the Genome Stability Network (GSN) for supporting the scientific programme. Hence, the conference will provide a unique opportunity to meet colleagues working in this research field in the UK and abroad.

The venue of the conference is the Franklin-Wilkins Building at the Waterloo Campus of King’s College London, directly in the heart of the city centre. With its history, culture, flair, nightlife and world-leading research institutions, London is the perfect location for the next UKEMS conference.

Thanks to UKEMS, the MRC-PHE Centre for Environment & Health and other sponsors, the conference registration fee and the accompanied cost for university accommodation have been deliberately kept low as reasonable as possible to encourage wide participation in the conference. Participation of young scientists (i.e. PhD students) at even further reduced rates is strongly encouraged and UKEMS is offering a number of travel bursaries to UKEMS members.

The conference will consist of a large variety of invited speakers and keynote lectures. Selected abstracts will be chosen for short oral presentation. We will also have a dedicated young scientist and junior investigator symposium. In addition, we will have poster sessions and we kindly invite all participants to present their work. All abstracts will be published online in the journal Mutagenesis. Presentation prizes sponsored by UKEMS and Mutagenesis will be awarded based on their scientific merit, judged by an eminent panel.

The conference dinner will be held at the Great Hall on the Strand Campus of King’s College London. The Great Hall forms part of the founding building for the university, constructed between 1829 and 1831. It was a sign of the prestige of the project that King’s had to decline the free services of Sir John Nash, architect of Buckingham Palace, in favour of those of Sir Robert Smirke, architect of the British Museum, because Smirke was already the architect of the university’s neighbour, Somerset House.

Once again we cordially invite you to participate at the 39th Annual Meeting of UKEMS in London, June 26th to 29th 2016. We look forward to welcoming you in London for an enjoyable and successful conference.

Dr. Volker M. Arlt

Local Organiser of the 39th Annual Meeting of UKEMS

Keynote Lectures:

  • Sir Michael Stratton, Hinxton
  • Alan Lehmann, Brighton
  • Jos Kleinjans, Maastricht, The Netherlands

Speakers already confirmed for the conference:

Causes of Mutational Signatures:

  • Peter Campbell, Hinxton
  • Steve Jackson, Cambridge
  • Bettina Meier, Dundee
  • Serena Nik-Zainal, Cambridge
  • Jill Kucab, London

Transgenic Mouse Models to Elucidate Pathways of Mutagenicity and Carcinogenicity:

  • Paul White, Ottawa, Canada
  • Mirjam Luijten, Bilthoven, The Netherlands
  • Volker Arlt, London

Risk Assessment and Regulatory Decision-making Based in Quantitative Analysis of Genetic Toxicology:

  • Wout Slob, Bilthoven, The Netherlands
  • George Johnson, Swansea
  • James Harvey, Herts

UK Industrial Genotoxicity Group Session:

  • Vasily Dobrovolsky, Jefferson, USA
  • Ann Doherty, Cambridge
  • Mirjam Luijten, Bilthoven, The Netherlands
  • Carol Beevers, Harrogate

Particle-induced Lung Inflammation and Genotoxicity

  • Frank Kelly, London
  • Martin Leonard, Harwell
  • Ian Jarvis, London
  • Ian Mudway, London
  • Chang Guo, Harwell
  • Terry Tetley, London
  • Andrew Thorley, London

UK Molecular Epidemiology Group Session – Exposomics:

  • Paolo Vineis, London
  • Nicole Probsch-Hensch, Basel, Switzerland
  • George Preston, London
  • John Gulliver, London
  • Augustin Scalbert, Lyon, France
  • Christina Villanueva, Barcelona, Spain

Jun
26
Sun
Registration
Jun 26 @ 1:00 pm – 5:00 pm
Pre-Meeting Educational Symposium – Young Scientists @ Lecture Theatre B5
Jun 26 @ 2:00 pm – 3:00 pm

Quantitative Assessement of Genetic Toxicology Data
Organiser & Presenter: George Johnson (Swansea University)

14:00 – 14:10 Introduction

14:10 – 15:00 ‘How to’ session using the statistical tools on www.mutait.org for deriving point of departure metrics. Focus on no observed effect levels, bilinear models and smoothing regression spline modelling.

Recommend reading: Johnson-GE et al (2014) Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ. Mol. Mutagen. 55(8):609-623.

Note: Participants are encouraged to bring their own laptop and/or tablet device for an interactive session.

Coffee Break
Jun 26 @ 3:00 pm – 3:30 pm
Pre-Meeting Educational Symposium – Young Scientists: contd.
Jun 26 @ 3:30 pm – 4:30 pm

15:30 – 16:10 ‘How to’ session using the statistical tools on www.mutait.org for deriving point of departure metrics. Focus on bench mark dose (BMD) approach using online version of PROAST.

16:10 – 16:30 Advanced applications of the BMD approach using online version of PROAST.

Recommend reading: Johnson-GE et al (2014) Derivation of point of departure (PoD) estimates in genetic toxicology studies and their potential applications in risk assessment. Environ. Mol. Mutagen. 55(8):609-623.

Note: Participants are encouraged to bring their own laptop and/or tablet devise for an interactive session.

Opening of Conference
Jun 26 @ 5:00 pm – 7:15 pm

Welcome from Frank Martin (UKEMS President) & Volker Arlt (King’s College London)

Keynote Opening Lecture
Jun 26 @ 5:15 pm – 6:15 pm

Genetic and clinical heterogeneity in the DNA repair disorder xeroderma pigmentosum

Alan Lehmann (University of Sussex, Brighton)

Welcome Reception with hot buffet
Jun 26 @ 6:15 pm – 7:30 pm
Jun
27
Mon
Causes of Mutational Signatures (Symposium sponsored by COMSIG Consortium)
Jun 27 @ 8:45 am – 10:30 am

08:45 – 09:30 Keynote Lecture:

Chairs: Steve Jackson (University of Cambridge) & Simon Reed (Cardiff University)

Signatures of mutational processes in human cancer
Sir Michael Stratton (Wellcome Trust Sanger Institute, Hinxton)

09:30 – 10:00 Pan-cancer analysis of genomic rearrangements
Peter Campbell (Wellcome Trust Sanger Institute, Hinxton)

10:00 – 10:30 Mechanisms of DNA-damage detection, signalling and repair
Steve Jackson (University of Cambridge, Cambridge)

Coffee Break
Jun 27 @ 10:30 am – 11:00 am

10:30 – 11:00 Coffee Break

Causes of Mutational Signatures (Symposium sponsored by COMSIG Consortium) cont.
Jun 27 @ 11:00 am – 12:30 pm

11:00 – 11:30 Mutation signatures of carcinogen exposure in the genome
Jill Kucab (King’s College London, London)

11:30 – 12:00 Massive C. elegans whole-genome sequencing for profiling mutational signatures of carcinogens and DNA repair deficiency
Bettina Meier (University of Dundee, Dundee)

12:00 – 12:30 Advances in the understanding of mutational signatures in human cells
Serena Nik-Zainal (Wellcome Trust Sanger Institute, Hinxton)

Lunch break
Jun 27 @ 12:30 pm – 1:30 pm

12:30 – 13:30 Lunch Break

Poster Session (Young Scientists)
Jun 27 @ 1:30 pm – 2:00 pm

13:30 – 14:00 Poster Session (Young Scientists)

Transgenic Mouse Models to Elucidate Pathways of Mutagenicity and Carcinogenicity
Jun 27 @ 2:00 pm – 3:30 pm

Chairs: Volker M. Arlt (King’s College London) & Michael Routledge (University of Leeds)

14:00 – 14:30: The mutagenic and carcinogenic hazards of PAHs in complex mixtures
Paul White (Health Canada, Ottawa, Canada)

14:30 – 15:00: The usefulness of a transgenic-mouse derived in vitro model to assess mutagenic hazard
Mirjam Luijten (National Institute for Public Health and the Environment, Bilthoven, The Netherlands)

15:00 – 15:30: The impact of p53 on DNA damage and metabolic activation of environmental carcinogens: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice
Volker M. Arlt (King’s College London)

Coffee Break
Jun 27 @ 3:30 pm – 4:00 pm

15:30 – 16:00 Coffee Break

Risk Assessment and Regulatory Decision-making Based in Quantitative Analysis of Genetic Toxicity
Jun 27 @ 4:00 pm – 6:00 pm

Chairs: Paul White (Health Canada, Ottawa, Canada) & Mick Fellows (AstraZeneca)

16:00 – 16:30: Recent developments in the analysis of genetic toxicity dose-response data: What can we learn from them when developing a risk assessment paradigm for genetic effects?
Wout Slob (National Institute for Public Health and the Environment, Bilthoven, The Netherlands)

16:30 – 17:30: Using standard in vivo genotoxicity studies and benchmark dose modelling to determine acceptable daily intakes for mutagenic impurities
George Johnson (Swansea University)
James Harvey (GSK)

17:30 – 17:45: BMD-covariate analyses for multiple genotoxicity endpoints permit robust, cross-tissue comparisons of Muta™Mouse responses to orally-delivered benzo[a]pyrene
Alexandra Long (Health Canada, Ottawa, Canada)

17:45 – 18:00: The influence of dose-spacing and choice of critical effect size (CES) for benchmark-dose modeling
Andreas Zeller (F. Hoffmann-La Roche, Basel, Switzerland)

Conference Dinner
Jun 27 @ 7:30 pm – 11:30 pm

19:30 – 23:30: Conference Dinner at the Great Hall on the Strand

Jun
28
Tue
UKEMS Young Scientist Award
Jun 28 @ 8:45 am – 9:30 am
Young Scientists & New Investigators
Jun 28 @ 9:30 am – 10:30 am

Chairs: Ruth Morse (University of the West of England) & George Johnson (Swansea University)
 
09:30 – 09:45 Selected abstract (Young Scientist)
09:45 – 10:00 Selected abstract (Young Scientist)
10:00 – 10:15 Selected abstract (Young Scientist)
10:15 – 10:30 Selected abstract (Young Scientist)

Coffee Break
Jun 28 @ 10:30 am – 11:00 am
Young Scientists & New Investigators
Jun 28 @ 11:00 am – 12:00 pm

11:00 – 11:20 Selected abstract (New Investigator)
11:20 – 11:40 Selected abstract (New Investigator)
11:40 – 12:00 Selected abstract (New Investigator)

UKEMS AGM
Jun 28 @ 12:00 pm – 1:00 pm
Lunch Break
Jun 28 @ 1:00 pm – 2:00 pm
IGG – UK Industrial Genotoxicity Group Session
Jun 28 @ 2:00 pm – 3:30 pm

Chairs: Julia Kenny (GSK) & Patricia Ellis (AstraZeneca)
 
14:00 – 14:30 Sequencing of the Pig-A mutation in vivo
Vasily Dobrovolsky (National Center for Toxicological Research, Jefferson, USA)

14:30 – 15:00 OECD Requirements for historical control ranges & control charts
Carol Beevers (Covance)

15:00 – 15:30 Achieving 3Rs benefits by provision of detailed OECD guidance: the in vitro micronucleus test as a case study
Mirjam Luijten (Bilthoven, The Netherlands)

NIHR Health Protection Research Unit in Health Impact of Environmental Hazards Investigator Symposium on Particle-induced lung inflammation and genotoxicity : Parallel Session
Jun 28 @ 2:00 pm – 3:30 pm

Chairs: Frank Kelly (King’s College London) & Timothy Gant (Public Health England)
 
14:00 – 14:30    Urban air pollution – here we go again
Frank Kelly (King’s College London)       
 
14:30 – 14:50 Asthma, genetic susceptibility and environmental pollutant exposures
Martin Leonard (Public Health England)              
 
14:50 – 15:10    Assessment of the toxic response to PM and diesel exhaust in human airway epithelial cultures
Ian Jarvis (King’s College London)
 
15:10 – 15:30    Establishing biomarkers of traffic exposure and systemic oxidative stress in children within the urban environment
Ian Mudway (King’s College London)

Coffee Break
Jun 28 @ 3:30 pm – 4:00 pm
NIHR Health Protection Research Unit in Health Impact of Environmental Hazards Investigator Symposium on Particle-induced lung inflammation and genotoxicity: Parallel Session @ Stamford Street Lecture Theatre
Jun 28 @ 4:00 pm – 5:00 pm

16:00 – 16:20   Pulmonary toxicity of silver nanoparticles investigated using an air liquid interface system
Chang Guo (Public Health England)
 
16:20 – 16:40   Bioreactivity of engineered nanomaterials at the pulmonary gas-liquid interface
Terry Tetley (Imperial College London)
 
16:40 – 17:00    Genotoxic and inflammatory effects of silver nanoparticles in the lung
Andrew Thorley (Imperial College London)

UK Industrial Genotoxicity Group Session
Jun 28 @ 4:00 pm – 5:00 pm

16:00 – 16:30 Is non-disjunction a more sensitive marker than chromosome loss for aneugenicity
Ann Doherty (AstraZeneca)

16:30 – 16:45 Selected abstract
TBC
 
16:45 – 17:00 Selected abstract
TBC

Poster Session
Jun 28 @ 5:00 pm – 7:00 pm

Poster Session with wine/juice

First hour odd numbers posters, second hour even numbered posters
 

Jun
29
Wed
UK Molecular Epidemiology Group Session – EXPOsOMICS
Jun 29 @ 8:45 am – 10:30 am

Chairs: Paolo Vineis (Imperial College London) & TBC
 
08:45 – 09:30 Keynote Lecture:
 
Transcriptomics responses among environmentally exposed study populations
Jos Kleinjans (Maastricht University)
 
09:30 – 10:00 The exposome in the context of causal reasoning and risk assessment
Paolo Vineis (Imperial College London)
 
10:00 – 10:30 Challenges in investigating the asthma exposome
Nicole Probst-Hensch (Swiss Tropical and Public Health Institute, Basel, Switzerland)

Coffee Break
Jun 29 @ 10:30 am – 11:00 am

Coffee Break

UK Molecular Epidemiology Group Session – EXPOsOMICS
Jun 29 @ 11:00 am – 1:00 pm

11:00 – 11:30 Exposure to disinfection by-products in swimming pools and associated early effect biomarkers
Cristina Villanueva (Centre for Research in Environmental Epidemiology, Barcelona, Spain)

11:30 – 12:00 Metabolomics and the exposome in epidemiology
Augustin Scalbert (International Agency for Research on Cancer, Lyon, France)

12:00 – 12:30 Air pollution measurements and modelling to characterise the external exposome
John Gulliver (Imperial College London)

12:30 – 13:00 Probing the internal exposome using untargeted albumin adductomics
George Preston (King’s College London)

Closing Remarks & Conference Ends
Jun 29 @ 1:00 pm – 1:15 pm

This year’s conference topics and poster session themes are listed below:

  • Causes of mutational signatures
  • Genome Stability: DNA Replication, Transcription and Repair in Diseases
  • Mouse models to elucidate pathways of mutagenicity and carcinogenicity
  • Risk assessment and regulatory decision-making in quantitative analysis of genetic toxicology
  • Current issues in industrial genotoxicity & regulatory updates
  • Air pollution & particle-induced lung inflammation and genotoxicity
  • Nanotoxicology
  • Molecular Epidemiology
  • EXPOsOMICS & New Biomarkers
  • Application of alternative approaches to animal testing
  • Cancer Prevention
  • Ecotoxicology
  • Young Scientist & Junior Investigator Session; Poster Session; Plenary and Award Lectures

MRC-PHE Centre for Environment & HealthMRC-PHE logo

The MRC-PHE Centre for Environment and Health exists to undertake the highest quality research in the fields of environment and health, in order to inform health policy and the understanding of key issues affecting society. The Centre will achieve this by bringing together the best researchers from all areas of public health, encouraging novel cross-disciplinary approaches, and providing the highest quality training to new and existing researchers in these fields. The Centre was formed in June 2009 as a partnership between Imperial College (lead institution) and King’s College London, funded by the Medical Research Council (MRC) and Health Protection Agency (now Public Health England, PHE).

More information can be found at www.environment-health.ac.uk.

COMSIG (Causes Of Mutational SIGnatures) consortium

Comsig logoMost human cells acquire somatic mutations in their DNA throughout life. Somatic mutations cause human diseases, particularly cancer. However, each cell contains complex DNA repair machinery that reduces mutation accumulation. When this machinery goes wrong, cells can acquire even more mutations, further contributing to disease development, but the causes of most somatic mutations are still unknown. The COMSIG consortium, funded by the Wellcome Trust, brings together scientists with distinct and complementary expertise to define mutational signatures caused by many chemicals and types of radiation, and by various types of defective DNA repair in model systems. The project aims to advance our understanding of how somatic mutations cause disease and could also suggest new avenues for diagnosis and treatment. The COMSIG consortium is coordinated by Professor Stephen Jackson (The Gurdon Institute, University of Cambridge) and Professor Sir Michael Stratton (Wellcome Trust Sanger Institute, Hinxton).

EXPOsOMICS

expos logoThe EXPOsOMICS project, funded by the European Union, aims to develop a new approach to assess environmental exposures, primarily focusing on air pollution and water contaminants. The exposome concept refers to the totality of environmental exposures from conception onwards, and is a novel approach to studying the role of the environment in human disease. Using ‘omic’ techniques the collected exposure data can be linked to biochemical and molecular changes in our body. The results will help to improve our understanding on how these pollutants influence the risk of developing chronic diseases. Imperial College (Professor Paolo Vineis) is the coordinator of the EXPOsOMICS consortium but is one of the thirteen project participants.

More information can be found at www.exposomicsproject.eu.

HPRU in Health Impact of Environmental Hazards

HPRU logoThe National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Health Impact of Environmental Hazards is a partnership between King’s College London, Public Health England (PHE) and Imperial College. The Unit is directed by Professor Frank Kelly (King’s) with Professor Tim Gant the PHE Lead and Professor Paul Elliott the Imperial College Lead.
The strategy of the NIHR HPRU in Health Impact of Environmental Hazards is to investigate the impact of exposure to exogenous environmental chemicals and other pollutants, to gain greater understanding of the mechanism of their interaction with human systems and hence generate new knowledge on health risks to the human population. This new knowledge will be used in health impact assessment and targeted policy research to inform and improve public health and medical response.

More information can be found at http://hieh.hpru.nihr.ac.uk.

German Society for Research on DNA Repair (DGDR)

Screen Shot 2016-03-16 at 07.38.04Scientists with a background in various natural and medical sciences joined forces to establish the German Society for Research on DNA Repair (DGDR) in order to promote research on DNA repair in German-speaking countries. The society serves as a platform for communication between the members and as an exchange network with other scientists engaged in basic, clinical or industrial research, who are interested in DNA repair and related areas. Since 1990 the society holds DNA Repair Meetings every two years with different main topics within the field of DNA repair. The next biannual Meeting of DGDR will take place in Essen, Germany, 12-16 September 2016.

More information can be found at http://dna-repair.de.

Mutagenesis LogoMutagenesis is an international multi-disciplinary journal designed to bring together research aimed at the identification, characterization and elucidation of the mechanisms of action of physical, chemical and biological agents capable of producing genetic change in living organisms and the study of the consequences of such changes. Mutagenesis is published by Oxford University Press together with UKEMS.

http://mutage.oxfordjournals.org/

Thank you to our sponsors:

MRC-PHE logo

Comsig logo expos logo HPRU logo

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